Иммунотерапия и CAR-T

KEYNOTE-966 Long-Term Follow-Up and Comparative Safety of Chemoimmunotherapy

New oral nanomedicine boosts effectiveness of cancer immunotherapies

Immune checkpoint blockade is a form of cancer treatment that works by releasing the natural brakes on the immune system, allowing T cells to find and destroy cancer cells. Although it has transformed cancer immunotherapy, patients usually have low response rates. In a new study published in Nature Nanotechnology…

New mRNA immunotherapy eliminates pancreatic tumors in mice

Inspired by the work of the RNA Therapeutics Institute at UMass Chan Medical School and the development of the COVID vaccine, Marcus Ruscetti, Ph.D., and Chaitanya Naimesh Parikh, Ph.D. '26, have developed an immunotherapy using a cocktail of messenger RNAs (mRNA) that could potentially transform pancreatic cancer…

Restoring aging T cell function to make them effective at fighting cancer

In a new study, Mass General Brigham researchers explore the causes of immune aging, a barrier to successful cancer immunotherapy, and identify a gene that may serve as an age-related prognostic marker and potential target for future cancer therapies.

Scientists turn probiotic bacteria into tiny drug factories for pancreatic cancer

Engineered probiotic bacteria were able to infiltrate pancreatic tumors, stimulate cancer-fighting immune cells, and slow tumor growth in animal studies. Even more strikingly, the treatment worked better when combined with chemotherapy, radiation, or immunotherapy.

A protein older than blood circulation could transform cancer immunotherapy

A protein that evolved long before the human circulatory system may help unlock stronger cancer treatments. When C3 is produced inside tumors, it blocks immune-suppressing cells and gives immunotherapy a better chance to work. Researchers were even able to recreate this effect in resistant tumors, significantly…