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Онкология

Investigators identify a metabolic weak point in exhausted immune cells in head and neck cancer

Immune cells can reach head and neck tumors, but once there, many stop functioning. This helps explain why immunotherapy with immune checkpoint inhibitors—which have transformed treatment for some cancers—benefits only 17%–23% of patients with head and neck squamous cell carcinoma. These are cancers that arise from…

Онкология

Thymus health may impact mortality, cancer outcomes in adults

When Hugo Aerts, PhD, started asking colleagues whether the thymus could play a role in determining which patients with cancer would respond to immunotherapy about 4 years ago, the responses were overwhelmingly dismissive. “It’s irrelevant,” they told him. “[The thymus is] important in kids. Afterwards, it doesn’t…