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Онкология

Age and sex shape cancer immunity, mouse experiments and human data suggest

A new study published in Nature Aging combines mouse experiments and human data sets to explore how biological sex and aging shape cancer immunity, with implications for immunotherapy responses. Lutz Menzel, Ph.D., formerly of the Department of Radiation Oncology within the Mass General Brigham Cancer Institute, is…

Онкология

Scientists uncover two-pronged strategy to overcome glioblastoma's resistance to immunotherapy

Scientists at The Wistar Institute have identified a combination treatment that overcomes two of the biggest barriers to immunotherapy in glioblastoma. In a study published in Neuro-Oncology, the researchers show that reprogramming myeloid cells, a type of immune cell that glioblastoma tumors co-opt to protect…

Онкология

Surgical de-escalation an option for locally advanced HNSCC

Surgical volume could be reduced for patients with locally advanced head and neck squamous cell carcinoma who respond to neoadjuvant chemoimmunotherapy. Data from a phase 2 trial showed individuals with HPV-negative disease, who achieved at least a 50% reduction in primary tumor burden after neoadjuvant treatment, and…