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Онкология

Heavily immunosuppressed patients undergoing anticancer immunotherapy face increased risk of severe infections

Immune checkpoint inhibitors (ICIs) can promote antitumor responses but can also cause adverse effects that require treatment with immunosuppressive drugs. A new retrospective study by Mass General Brigham Cancer Institute investigators found that patients who received ICIs and multiple immunosuppressive therapies…

Онкология

Scientists find the gene that drives T-cell exhaustion, revealing new strategy to improve immune responses

Immunotherapy, which uses a patient's immune system to treat disease, has increased survival for some adults and children with cancer. However, it has had limited success against many pediatric solid tumors, in part because T cells can become functionally impaired or "exhausted." St. Jude Children's Research Hospital…

Онкология

Global Bladder Cancer Treatment Market to Reach USD 11.33 Billion by 2034, Driven by Rising Disease Burden, Growing Adoption of Immunotherapy, and Advances in Targeted Cancer Therapies Reports Maximize Market Research

Global Bladder Cancer Treatment Market to Reach USD 11.33 Billion by 2034, Driven by Rising Disease Burden, Growing Adoption of Immunotherapy, and Advances in Targeted Cancer Therapies Reports Maximize Market Research Yahoo Finance

Онкология

Global Bladder Cancer Treatment Market to Reach USD 11.33 Billion by 2034, Driven by Rising Disease Burden, Growing Adoption of Immunotherapy, and Advances in Targeted Cancer Therapies Reports Maximize Market Research

Global Bladder Cancer Treatment Market to Reach USD 11.33 Billion by 2034, Driven by Rising Disease Burden, Growing Adoption of Immunotherapy, and Advances in Targeted Cancer Therapies Reports Maximize Market Research PR Newswire

Онкология

Study identifies potential RAS inhibitor-immunotherapy strategy for pancreatic cancer

Pancreatic cancer does not respond to most immunotherapies, but RAS inhibitors could alter tumors to make them more sensitive to a novel immunotherapeutic approach. In pancreatic tumors with RAS mutations, RAS inhibitors cause massive cell death and reduce immunosuppression. These changes tend to be temporary because…

Онкология

Rheumatic immune-related adverse events with immune checkpoint inhibitors more severe than previously reported

For patients receiving immune checkpoint inhibitors (ICIs), rheumatic immune-related adverse events (rh-irAEs) are usually moderate or severe, with more than one-third leading to permanent ICI discontinuation, according to a study published online Sept. 8 in ACR Open Rheumatology.