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Онкология

How mutation disrupts cell development, driving region-specific brain tumors

Scientists at St. Jude Children's Research Hospital have shown that specific brain cells respond differently to H3.3 K27M, a mutation in the histone H3.3 protein that drives many cases of diffuse midline glioma (DMG), depending on the cells' location in the developing brain. These findings help explain why DMG, a…

Онкология

‘Substantial’ use of cancer drugs with no survival benefit

The percentage of oral targeted anticancer drugs used for indications with label-documented evidence of survival benefit increased between 2016 and 2021, according to a review of claims data from a large national insurer. However, researchers still observed what they called “significant” use of — and spending on —…

Онкология

Blocking cellular 'freecycling' may slow bone marrow scarring in myelofibrosis

In a new study published in Nature Communications, Boston Children's Hospital researchers identified a new target responsible for scar formation in the bone marrow of patients with a type of blood cancer known as myelofibrosis. Combining traditional myelofibrosis therapy with drugs that block scar formation may be a…

Онкология

First-in-human pilot trial improves stem cell collection and delivery for sickle cell gene therapy

Patients with sickle cell disease are often hesitant to undergo transformative gene therapy—the current lengthy process requires multiple hospital visits to collect enough stem cells. Researchers from Boston Children's Hospital have helped smooth the road to gene therapy with a new approach that collects enough of the…