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Онкология

How loss of the critical tumor suppressor p53 enables mutant cells to expand through normal tissue

A protein known as p53 is, of all tumor suppressors in human cancer, the most frequently altered by gene mutations. When mutations cause it to be absent or nonfunctional, its loss can allow populations of mutant cells to expand through normal tissue. Researchers have long known that loss of p53 does more than remove a…

Онкология

Discovery explains how immune cells target DNA mutations to improve antibodies

Scientists at the Montreal Clinical Research Institute (IRCM), led by Université de Montréal medical professor Javier Di Noia, have shed light on a fundamental mystery in immunology: How do immune cells manage to concentrate a powerful mutagenic enzyme at precisely defined regions of DNA while largely sparing the rest…