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Онкология

RNA creates a self-destruct switch for cellular machinery linked to leukemia

Cells have all kinds of intricate machinery to control genes, switching them on and off at the right times and under the right conditions. Components of this machinery include chromatin-modifying complexes, groups of proteins that manage how tightly DNA is packaged in the nucleus and control how accessible it is for…

Онкология

AI-designed proteins outperform existing CAR T designs against BCMA tumors in mice

CAR T cell therapy, which involves genetically modifying a patient's own immune cells to fight cancer, is a technique that has shown great promise, especially against blood cancers. But currently, only about 4% of patients with advanced or metastatic cancer in the United States are candidates for CAR T therapy, and…